Rang and Dale's Pharmacology
- London Elsevier
- 789p.
Description Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.
Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.
This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.
Table of contents Instructions for online access Cover image Title page Table of Contents How to Use Copyright Video and Case Study Contents Inflammation case study Cardiovascular case study Respiratory case study Food and glucose regulation case study Neurodegenerative disease case study Epilepsy case study Cancer case study Videos Contents Rang & Dale’s Pharmacology Tenth Edition Preface Section 1. GENERAL PRINCIPLES 1. What is pharmacology? What is a Drug? Origins and Antecedents Pharmacology in the 20th and 21st Centuries 2. How drugs act: general principles Introduction Protein Targets for Drug Binding Desensitisation and Tolerance Quantitative Aspects of Drug–Receptor Interactions The Nature of Drug Effects 3. How drugs act: molecular aspects Protein Targets for Drug Action Receptor Proteins Ion Channels as Drug Targets Control of Receptor Expression Receptors and Disease 4. How drugs act: cellular aspects – excitation, contraction and secretion Regulation of Intracellular Calcium Excitation Muscle Contraction Release of Chemical Mediators Epithelial Ion Transport 5. How drugs act: biopharmaceuticals and gene therapy INTRODUCTION PROTEIN AND PEPTIDE BIOPHARMACEUTICALS OLIGONUCLEOTIDES GENE THERAPY SAFETY AND SOCIETAL ISSUES THERAPEUTIC APPLICATIONS FUTURE DIRECTIONS 6. Cell proliferation, apoptosis, repair and regeneration Cell Proliferation Angiogenesis Apoptosis and Cell Removal Pathophysiological Implications Therapeutic Prospects 7. Cellular mechanisms: host defence Introduction The Innate Immune Response The Adaptive Immune Response Systemic Responses in Inflammation 8. Method and measurement in pharmacology BIOASSAY ANIMAL MODELS OF DISEASE PHARMACOLOGICAL STUDIES IN HUMANS CLINICAL TRIALS CLINICAL CONSIDERATION OF BENEFIT AND RISK 9. Absorption and distribution of drugs Introduction Physical Processes Underlying Drug Disposition Drug Absorption and Routes of Administration Distribution of Drugs in the Body Special Drug Delivery Systems 10. Drug metabolism and elimination INTRODUCTION DRUG AND METABOLITE EXCRETION 11. Pharmacokinetics Introduction: Definition and uses of Pharmacokinetics Drug Elimination Expressed as Clearance Single-Compartment Model More Complicated Kinetic Models Population Pharmacokinetics Limitations of Pharmacokinetics 12. Individual variation, pharmacogenomics and personalised medicine Introduction Epidemiological Factors and Inter-Individual Variation of Drug Response Genetic Variation in Drug Responsiveness Therapeutic Drugs and Clinically Available Pharmacogenomic Tests Conclusions Section 2. CHEMICAL MEDIATORS 13. Chemical mediators and the autonomic nervous system Historical Aspects The Autonomic Nervous System Some General Principles of Chemical Transmission Basic Steps in Neurochemical Transmission: Sites of Drug Action 14. Cholinergic transmission Muscarinic and Nicotinic Actions of Acetylcholine Acetylcholine Receptors Nicotinic Receptors Physiology of Cholinergic Transmission Effects of Drugs on Cholinergic Transmission 15. Noradrenergic transmission Catecholamines Classification of Adrenoceptors Physiology of Noradrenergic Transmission Drugs Acting on Noradrenergic Transmission 16. 5-Hydroxytryptamine and the purines 5-Hydroxytryptamine Clinical Conditions in Which 5-HT Plays a Role Purines Purinergic Receptors The Purinergic System in Health and Disease Purines as Neurotransmitters Summary 17. Local hormones: histamine, lipids, peptides and proteins Introduction What is a ‘Mediator’? Histamine Eicosanoids Leukotrienes Other Important Fatty Acid Derivatives Platelet-Activating Factor Sphingosine 1-Phosphate Protein and Peptide Mediators Biosynthesis and Regulation of Peptides Bradykinin Neuropeptides Cytokines Proteins and Peptides that Down-Regulate Inflammation Concluding Remarks 18. Cannabinoids Plant-Derived Cannabinoids (‘Phytocannabinoids’) And Their Pharmacological Effects Cannabinoid Receptors Endocannabinoids Synthetic Cannabinoids Clinical Applications 19. Nitric oxide and related mediators Introduction Biosynthesis of Nitric Oxide and its Control Degradation and Carriage of Nitric Oxide Effects of Nitric Oxide Therapeutic Aspects Clinical Conditions in Which Nitric Oxide May Play a Part Related Mediators Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS 20. The heart Introduction Physiology of Cardiac Function Autonomic Control of the Heart Cardiac Natriuretic Peptides Ischaemic Heart Disease Drugs that Affect Cardiac Function 21. The vascular system Introduction Vascular Structure and Function Control of Vascular Smooth Muscle Tone Vasoactive Drugs Clinical Uses of Vasoactive Drugs 22. Atherosclerosis and lipoprotein metabolism Introduction Atherogenesis Lipoprotein Transport Prevention of Atheromatous Disease Lipid-Lowering Drugs Antisense Oligonucleotides 23. Haemostasis and thrombosis Introduction Blood Coagulation Drugs that Act on the Coagulation Cascade Platelet Adhesion and Activation Fibrinolysis (Thrombolysis) 24. Haematopoietic system and treatment of anaemia Introduction The Haematopoietic System Types of Anaemia Haematinic Agents Haematopoietic Growth Factors Haemolytic Anaemia 25. Anti-inflammatory and immunosuppressant drugs Introduction Cyclo-Oxygenase Inhibitors Antirheumatoid Drugs BIOLOGIC DISEASE-MODIFYING ANTIRHEUMATIC DRUGS, ANTICYTOKINE DRUGS AND OTHER BIOPHARMACEUTICALS Drugs Used in Gout Antagonists of Histamine Possible Future Developments in Anti-Inflammatory Therapy 26. Skin Introduction Structure of Skin Common Diseases of the Skin Drugs Acting on Skin Principal Drugs Used in Skin Disorders Agents Acting by Other Mechanisms Concluding Remarks 27. The eye Introduction Special Pharmacokinetic Considerations in the Eye Treatment of Inflammation and Infection in the Eye Control of Intraocular Pressure and Treatment of Glaucoma Ocular Vasculature and Vascular Endothelial Growth Factor Inhibitors 28. Respiratory system The Physiology of Respiration Pulmonary Disease and its Treatment 29. The kidney and urinary system Introduction Outline of Renal Function The Structure and Function of the Nephron Drugs Acting on the Kidney Drugs that Alter the pH of the Urine Drugs that Alter the Excretion of Organic Molecules Drugs Used in Renal Failure Drugs Used in Urinary Tract Disorders 30. The gastrointestinal tract The Innervation and Hormones of the Gastrointestinal Tract Gastric Secretion Vomiting The Motility of the GI Tract Drugs for Chronic Bowel Disease Drugs Affecting the Biliary System Future Directions 31. The control of blood glucose and drug treatment of diabetes mellitus Introduction Control of Blood Glucose Pancreatic Islet Hormones Diabetes Mellitus 32. Obesity Introduction Obesity as a Health Problem Homeostatic Mechanisms Controlling Energy Balance The Pathophysiology of Human Obesity Pharmacological Approaches to the Problem of Obesity New Approaches to Obesity Therapy 33. The pituitary and the adrenal cortex The Pituitary Gland The Adrenal Cortex New Directions in Glucocorticoid Therapy 34. The thyroid Synthesis, Storage and Secretion of Thyroid Hormones Regulation of Thyroid Function Actions of the Thyroid Hormones Transport and Metabolism of Thyroid Hormones Abnormalities of Thyroid Function Drugs Used in Diseases of the Thyroid 35. The reproductive system Introduction Endocrine Control of Reproduction Drugs Affecting Reproductive Function Drugs Used for Contraception The Uterus Erectile Dysfunction 36. Bone metabolism Introduction Bone Structure and Composition Bone Remodelling Disorders of Bone Drugs Used in Bone Disorders Section 4. NERVOUS SYSTEM 37. Chemical transmission and drug action in the central nervous system Introduction Chemical Signalling in the Nervous System Targets for Drug Action Drug Action in the Central Nervous System The Classification of Psychotropic Drugs 38. Amino acid transmitters Excitatory Amino Acids Glutamate γ-AMINOBUTYRIC ACID Glycine Concluding Remarks 39. Other transmitters and modulators Introduction Noradrenaline Dopamine 5-Hydroxytryptamine Acetylcholine Purines Histamine Other CNS Mediators A Final Message 40. Neurodegenerative diseases Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases Mechanisms of Neuronal Death Ischaemic Brain Damage Dementia Parkinson’s Disease Essential Tremor Huntington’s Disease Amyotrophic Lateral Sclerosis Spinal Muscular Atrophy Multiple Sclerosis 41. General anaesthetic agents Overview Introduction Mechanism of Action of Anaesthetic Drugs Intravenous Anaesthetic Agents Inhalation Anaesthetics Individual Inhalation Anaesthetics Sedation and Balanced Anaesthesia 42. Headache Headache Types of Headaches Drug Therapy for Headache Summary 43. Analgesic drugs Introduction Neural Mechanisms of Pain Analgesic Drugs Chronic Pain 44. Local anaesthetics and other drugs affecting sodium channels Local Anaesthetics Other Drugs That Affect Sodium Channels 45. Anxiolytic and hypnotic drugs The Nature Of Anxiety And Its Treatment Measurement Of Anxiolytic Activity Drugs Used To Treat Anxiety Delayed Anxiolytic Effect Of Drugs Acting Via Serotonergic Mechanisms Drugs Used To Treat Insomnia (Hypnotic Drugs) 46. Antiepileptic drugs Overview Introduction The Nature of Epilepsy Antiepileptic Drugs Muscle Spasm and Muscle Relaxants 47. Antipsychotic drugs Introduction The Nature of Schizophrenia Antipsychotic Drugs Future Developments 48. Antidepressant drugs The Nature of Depression Theories of Depression Antidepressant Drugs Clinical Effectiveness of Antidepressant Treatments Future Antidepressant Drugs Brain Stimulation Therapies Drug Treatment of Bipolar Disorder 49. Psychoactive drugs Introduction Psychomotor Stimulants Cognition-Enhancing Drugs Psychedelic Drugs Dissociative Drugs Depressants Synthetic Cannabinoid Receptor Agonists 50. Drug use and addiction Drug Use Harm Reduction Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER 51. Basic principles of antimicrobial chemotherapy Background The Molecular Basis of Chemotherapy Resistance to Antibacterial Drugs Current Status of Antibiotic Resistance in Bacteria 52. Antibacterial drugs INTRODUCTION ANTIBACTERIAL AGENTS THAT INTERFERE WITH FOLATE SYNTHESIS OR ACTION β-LACTAM ANTIBIOTICS AND OTHER AGENTS THAT INTERFERE WITH BACTERIAL WALL OR MEMBRANE SYNTHESIS ANTIMICROBIAL AGENTS AFFECTING BACTERIAL PROTEIN SYNTHESIS ANTIMICROBIAL AGENTS AFFECTING TOPOISOMERASE MISCELLANEOUS ANTIBACTERIAL AGENTS ANTIMYCOBACTERIAL AGENTS PROSPECTS FOR NEW ANTIBACTERIAL DRUGS 53. Antiviral drugs Background Information About Viruses The Host–Virus Interaction HIV and AIDS COVID-19 Antiviral Drugs Combination Therapy For HIV COVID-19 Pharmacotherapy Prospects for New Antiviral Drugs 54. Antifungal drugs Fungi and Fungal Infections Drugs Used to Treat Fungal Infections Future Developments 55. Antiprotozoal drugs Background Host–Parasite Interactions Malaria and Antimalarial Drugs Amoebiasis and Amoebicidal Drugs Trypanosomiasis and Trypanocidal Drugs Other Protozoal Infections and Drugs Used to Treat Them Future Developments 56. Antihelminthic drugs Helminth Infections Antihelminthic Drugs Resistance to Antihelminthic Drugs Vaccines and Other Novel Approaches 57. Anticancer drugs Introduction The Pathogenesis of Cancer General Principles of Cytotoxic Anticancer Drugs Anticancer Drugs Future Developments Section 6. SPECIAL TOPICS 58. Harmful effects of drugs Introduction Classification of Adverse Drug Reactions Drug Toxicity Immunological Reactions to Drugs 59. Lifestyle and drugs in sport What are Lifestyle Drugs? Classification of Lifestyle Drugs Cognitive Enhancers Drugs and Sex Drugs in Sport Regulatory, Societal and Ethical Issues Conclusion 60. Drug discovery and development Drug Discovery: Background The Stages of a Project Biopharmaceuticals Commercial Aspects Future Prospects A Final Word Index